Trust Your Gut: Weight Loss and the Microbiome

  
When it comes to weight loss, diet and exercise usually take center stage, sometimes sharing the spotlight with weight loss medication. But research suggests that an often-overlooked factor—your gut microbiome—plays a critical role in how your body manages weight. Our resident registered dietitian (RD), Jessica Cording, helps us understand how the connection between gut health and weight loss can help you make more informed choices on your journey to a healthier you.
 
Your Gut Microbiome: As Unique as a Fingerprint
 
Your gut microbiome is made up of trillions of tiny organisms, like bacteria and fungi, that live in your digestive system. Everyone's gut microbiome is different, like a fingerprint. Many things affect it, including your genes, diet, lifestyle, and even how you were born (C-section or vaginal delivery).
 
Even though each person’s microbiome is unique, scientists have found patterns that connect gut health to weight. When people lose weight, their gut microbiome changes in ways that help improve their health. “The health of our gut microbiome is important for many aspects of wellness, and a growing body of research suggests that the gut microbiome may also play a role in weight management,” says Cording.
 
One change that can happen with weight loss is an increase in the variety of gut bacteria. A more diverse microbiome is linked to better digestion and improved metabolic health. Research suggests that losing more than 5% of body weight may lead to changes in gut bacteria diversity.
 
A Healthier Gut Microbiome = a Healthier You
 
Weight loss may also help strengthen the gut lining, reducing what’s called “leaky gut.” When the gut lining is too weak, harmful substances can enter the bloodstream and cause inflammation. As people lose weight, their gut lining may become stronger, which is important for overall health.
 
Losing weight doesn’t just make the gut microbiome more diverse—it may also shift it to look more like the microbiome of someone at a healthy weight. This change may lead to improvements in digestion and metabolism, along with helping in appetite control.
 
How to Support Gut Health While Losing Weight
 
Even though weight loss can naturally improve gut health, you can also take simple steps to help your microbiome (and your overall wellbeing):
 
Eat more fiber-rich and fermented foods: Whole foods help feed good gut bacteria. “To support a healthy gut microbiome, it’s generally recommended to consume plenty of fiber,” says Cording, while fermented foods (like yogurt, kimchi, and sauerkraut), “can help provide probiotic bacteria to populate the GI tract with good bacteria.”
Stay active and hydrated: Regular movement and drinking plenty of water support digestion and gut health.
More sleep, less stress: Quality rest and stress management can positively influence gut bacteria.
Limit processed foods and sugar:  “It’s also helpful to limit or avoid ultraprocessed foods and foods that are difficult for your body to digest,” Cording notes. These types of foods can feed harmful bacteria and throw your gut off balance.
Take a probiotic supplement: For some people, taking a prebiotic or probiotic supplement could help balance their microbiome. Talk to your healthcare provider to learn if this is right for you.
 
The connection between gut health and weight loss is still being studied, but one thing is clear: a healthy gut helps support a healthy weight. By making small, healthy changes, you can improve your gut microbiome while working toward your weight loss goals.
 
 
 
Jessica Cording, RD, is a registered dietitian, health coach, and author with a passion for helping people build sustainable healthy habits that support their mental and physical well-being.
 
Jessica Cording is a paid consultant of Currax Pharmaceuticals.
 

 

CON-2374-001 04/25

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Important Safety Information
What is CONTRAVE?
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CONTRAVE can cause serious side effects including:

Suicidal thoughts or actions: One of the ingredients in CONTRAVE is bupropion. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment.

CONTRAVE is a prescription weight-loss medicine that may help some adults with a body mass index (BMI) of 30 kg/m2 or greater (obese), or adults with a BMI of 27 kg/m2 or greater (overweight) with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes, lose weight and keep the weight off.

Important Safety Information
See More
CONTRAVE can cause serious side effects including:
Suicidal thoughts or actions: One of the ingredients in CONTRAVE is bupropion. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment.
What is CONTRAVE?
See More
CONTRAVE is indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of:
Important Safety Information
What is CONTRAVE?
See Less 

CONTRAVE can cause serious side effects including:

Suicidal thoughts or actions: One of the ingredients in CONTRAVE is bupropion. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment.

While taking CONTRAVE, you or your family members should pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when you start taking CONTRAVE or when your dose changes.

Stop taking CONTRAVE and call a healthcare provider right away if you or your family members notice any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying; attempts to commit suicide; depression; anxiety; feeling agitated or restless; panic attacks; irritability; aggression, anger, or violence; acting on dangerous impulses; an extreme increase in activity and talking; other unusual changes in behavior or mood; trouble sleeping.

CONTRAVE is not approved for use in children under the age of 18.

Do not take CONTRAVE if you have uncontrolled high blood pressure; have or have had seizures; use other medicines that contain bupropion such as WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, APLENZIN and ZYBAN; have or have had an eating disorder called anorexia or bulimia; are dependent on opioid pain medicines or use medicines to help stop taking opioids, or are in opiate withdrawal; drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy), benzodiazepines, or anti‐seizure medicines and stop using them all of a sudden; are taking or have taken medicines called monoamine oxidase inhibitors (MAOIs) in the past 14 days; or are allergic to any of the ingredients in CONTRAVE.

Tell your healthcare provider about all of your medical conditions, including if you have: depression or other mental illnesses; attempted suicide; seizures; head injury; tumor or infection of brain or spine; low blood sugar or low sodium; liver or kidney problems; high blood pressure; heart attack, heart problems, or stroke; eating disorder; drinking a lot of alcohol; prescription medicine or street drug abuse; are 65 or older; diabetes; pregnant or planning to become pregnant; or breastfeeding.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

CONTRAVE may cause serious side effects, including:

  • Seizures. There is a risk of having a seizure when you take CONTRAVE. The risk of seizure is higher in people who take higher doses of CONTRAVE, have certain medical conditions, or take CONTRAVE with certain other medicines. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider has said it is okay to take them. If you have a seizure while taking CONTRAVE, stop taking CONTRAVE and call your healthcare provider right away.

  • Risk of opioid overdose. Do not take large amounts of opioids, including opioid-containing medicines, such as heroin or prescription pain pills, to try to overcome the opioid-blocking effects of naltrexone. This can lead to serious injury, coma, or death.

    Get emergency medical help right away if you take opioids and you:

    • have trouble breathing

    • become very drowsy with slowed breathing

    • have slow, shallow breathing

    • feel faint, very dizzy, confused, or have unusual symptoms

  • Sudden opioid withdrawal. People who take CONTRAVE must not use any type of opioid, including street drugs, prescription pain medicines, cough, cold, or diarrhea medicines that contain opioids, or opioid dependence treatments, for at least 7 to 10 days before starting CONTRAVE. Using opioids in the 7 to 10 days before you start taking CONTRAVE may cause you to suddenly have symptoms of opioid withdrawal when you take it. Sudden opioid withdrawal can be severe, and you may need to go to the hospital. Tell your healthcare provider you are taking CONTRAVE before a medical procedure or surgery.

  • Severe allergic reactions. Stop taking CONTRAVE and call your healthcare provider or go to the nearest hospital emergency room right away if you have any of the following signs and symptoms of an allergic reaction: rash, itching, hives, fever, swollen lymph glands, painful sores in your mouth or around your eyes, swelling of your lips or tongue, chest pain, or trouble breathing.

  • Increases in blood pressure or heart rate. Some people may get high blood pressure or have a higher heart rate when taking CONTRAVE. Your healthcare provider should check your blood pressure and heart rate before you start taking, and while you take CONTRAVE.

  • Liver damage or hepatitis. Stop taking CONTRAVE and tell your healthcare provider if you have any of the following symptoms of liver problems: stomach area pain lasting more than a few days, dark urine, yellowing of the whites of your eyes, or tiredness. Your healthcare provider may need to stop treating you with CONTRAVE if you get signs or symptoms of a serious liver problem.

  • Manic episodes. Bupropion can cause some people who were manic or depressed in the past to become manic or depressed again.

  • Visual problems (angle-closure glaucoma). Signs and symptoms may include: eye pain, changes in vision, swelling or redness in or around the eye. Talk with your healthcare provider to find out if you are at risk for angle‐closure glaucoma and to get treatment to prevent it if you are at risk.

  • Increased risk of low blood sugar in people with type 2 diabetes mellitus who also take medicines to treat their diabetes (such as insulin or sulfonylureas). You should check your blood sugar before you start taking CONTRAVE and while you take CONTRAVE.

The most common side effects of CONTRAVE include nausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea. These are not all of the possible side effects of CONTRAVE.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

What is CONTRAVE?

CONTRAVE is a prescription weight-loss medicine that may help some adults with a body mass index (BMI) of 30 kg/m2 or greater (obese), or adults with a BMI of 27 kg/m2 or greater (overweight) with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes, lose weight and keep the weight off.

CONTRAVE should be used with a reduced-calorie diet and increased physical activity.

It is not known if CONTRAVE changes your risk of heart problems or stroke or of death due to heart problems or stroke.

It is not known if CONTRAVE is safe and effective when taken with other prescription, over-the-counter, or herbal weight-loss products.

CONTRAVE is not approved to treat depression or other mental illnesses, or to help people quit smoking (smoking cessation).

Please see Full Prescribing Information, including Medication Guide, for CONTRAVE.