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Weight Loss After Menopause

Menopause is inevitable, but no two women experience it the same way. This (plus centuries of not talking about women’s reproductive health in general...) means many women don’t know what to expect from their bodies in their post-menopausal years—and they especially don’t know what to do about the weight.

Weight Gain During Menopause: A Major Concern For Women 
Menopause marks the end of a woman’s potential childbearing years. A woman is considered to be post-menopausal after she has not experienced a period for one complete year. 

Weight gain is a documented symptom of the menopausal transition, with women gaining (on average) about one pound per year each year. About 20% of women will gain a significant amount of weight (≥10 lbs) and about 43% of post-menopausal women have a BMI of ≥30 kg/m2. It makes sense, then, that studies show weight gain is one of the menopausal symptoms women are most concerned about and want guidance on.

Low Estrogen is (Most Likely) The Culprit
Classic symptoms like hot flashes, brain fog, trouble sleeping, etc. are hallmarks of the menopausal transition, also known as perimenopause. These happen because of fluctuating levels of female sex hormones, including estrogen. 

After menopause, estrogen levels stay low. There may be some lingering perimenopausal symptoms but for the most part, it’s low estrogen that shapes your post-menopausal years. Low estrogen can make it harder for you to stay at a healthy weight in your 60s and beyond.

Estrogen is not just a sex hormone, it also plays a part in breaking down energy and making new cells in the body. As estrogen decreases, your metabolism starts to slow. Estrogen is also used by the body to make bone cells. With less estrogen, the bones become weaker and more susceptible to fracture or osteoporosis. 

When estrogen is low, the body changes where it decides to store fat. For most of a woman’s life, she will likely carry weight on the thighs and hips, versus the belly. However, that generally reverses post-menopause, when the body switches to storing fat in the abdomen—a more dangerous kind of fat called visceral fat that carries specific health risks, like cardiovascular disease. 

How the Natural Aging Process Plays a Role
Besides declining estrogen, other general age-related factors can contribute to a woman’s weight gain later in life. As the body ages, it naturally starts to need less energy, which means it needs fewer calories than it did before. Continuing to eat like you’ve always eaten can lead to overeating, which can cause you to gain weight.

Getting older is also associated with an increased risk of injury from falls or other accidents. Whether these injuries were acquired while you were physically active or not, recovering from them can keep you away from the gym. Some chronic injuries might even make it extremely difficult for you to exercise overall, which can also lead to weight gain.

Prioritize Health at Every Age
Centering your health and self-care may or may not become easier with age, but the foundations of a healthy lifestyle and achieving your weight loss goals are still the same!

Focus on eating a balanced and nutritious diet full of whole foods. It’s especially important in your later years to get enough protein to conserve your muscles. Talk to your healthcare provider or work directly with a registered dietician (RD) to determine the best nutritional prescription for you at your age, health, and activity level.

There’s no need to succumb to a trendy, “quick-fix” diet in your golden years! Consider eating smaller portion sizes of the foods you already like. This will help you meet your lower-calorie needs without depriving yourself of your favorites. 

Continue to prioritize getting your exercise in. Cardio exercises will not only get the heart pumping and fat burning, but they’ll also boost your cardiovascular health. Low-impact workouts can help keep you safe from injury, so you can keep moving. Incorporating strength training is a must-have, as well. It can help counter both the natural loss of muscle from aging and protect your bones from low estrogen.

When Diet and Exercise Alone Aren't Enough
Just like with menopause, weight loss in general is not a one-size-fits-all experience. One thing is clear, though—weight gain in menopause isn’t like any other kind of weight gain. If you’re in your postmenopausal years and struggling to lose weight despite diet and exercise, consider talking to your healthcare provider about other possible strategies to help lose weight. 

 

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IMPORTANT SAFETY INFORMATION
What is CONTRAVE?
See More

CONTRAVE can cause serious side effects including:
Suicidal thoughts or actions: One of the ingredients in CONTRAVE is bupropion. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment.

CONTRAVE is a prescription weight-loss medicine that may help some adults with a body mass index (BMI) of 30 kg/m2 or greater (obese), or adults with a BMI of 27 kg/m2 or greater (overweight) with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes, lose weight and keep the weight off.

IMPORTANT SAFETY INFORMATION
See More

CONTRAVE can cause serious side effects including:
Suicidal thoughts or actions: One of the ingredients in CONTRAVE is bupropion. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment.

What is CONTRAVE?
See More

CONTRAVE is a prescription weight-loss medicine that may help some adults with a body mass index (BMI) of 30 kg/m2 or greater (obese), or adults with a BMI of 27 kg/m2 or greater (overweight) with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes, lose weight and keep the weight off.

IMPORTANT SAFETY INFORMATION
What is CONTRAVE?
See Less

CONTRAVE can cause serious side effects including:
Suicidal thoughts or actions: One of the ingredients in CONTRAVE is bupropion. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment.

While taking CONTRAVE, you or your family members should pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when you start taking CONTRAVE or when your dose changes.

Stop taking CONTRAVE and call a healthcare provider right away if you or your family members notice any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying; attempts to commit suicide; depression; anxiety; feeling agitated or restless; panic attacks; irritability; aggression, anger, or violence; acting on dangerous impulses; an extreme increase in activity and talking; other unusual changes in behavior or mood; trouble sleeping.

CONTRAVE is not approved for use in children under the age of 18.

Do not take CONTRAVE if you have uncontrolled high blood pressure; have or have had seizures; use other medicines that contain bupropion such as WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, APLENZIN and ZYBAN; have or have had an eating disorder called anorexia or bulimia; are dependent on opioid pain medicines or use medicines to help stop taking opioids, or are in opiate withdrawal; drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy), benzodiazepines, or anti‐seizure medicines and stop using them all of a sudden; are taking or have taken medicines called monoamine oxidase inhibitors (MAOIs) in the past 14 days; or are allergic to any of the ingredients in CONTRAVE.

Tell your healthcare provider about all of your medical conditions including if you have: depression or other mental illnesses; attempted suicide; seizures; head injury; tumor or infection of brain or spine; low blood sugar or low sodium; liver or kidney problems; high blood pressure; heart attack, heart problems, or stroke; eating disorder; drinking a lot of alcohol; prescription medicine or street drug abuse; are 65 or older; diabetes; pregnant or planning to become pregnant; or breastfeeding.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

CONTRAVE may cause serious side effects, including:
  • Seizures. There is a risk of having a seizure when you take CONTRAVE. The risk of seizure is higher in people who take higher doses of CONTRAVE, have certain medical conditions, or take CONTRAVE with certain other medicines. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider has said it is okay to take them. If you have a seizure while taking CONTRAVE, stop taking CONTRAVE and call your healthcare provider right away.
  • Risk of opioid overdose. Do not take large amounts of opioids, including opioid-containing medicines, such as heroin or prescription pain pills, to try to overcome the opioid-blocking effects of naltrexone. This can lead to serious injury, coma, or death.

    Get emergency medical help right away if you take opioids and you:

    • have trouble breathing
    • become very drowsy with slowed breathing
    • have slow, shallow breathing
    • feel faint, very dizzy, confused, or have unusual symptoms
  • Sudden opioid withdrawal. People who take CONTRAVE must not use any type of opioid including street drugs, prescription pain medicines, cough, cold, or diarrhea medicines that contain opioids, or opioid dependence treatments, for at least 7 to 10 days before starting CONTRAVE. Using opioids in the 7 to 10 days before you start taking CONTRAVE may cause you to suddenly have symptoms of opioid withdrawal when you take it. Sudden opioid withdrawal can be severe, and you may need to go to the hospital. Tell your healthcare provider you are taking CONTRAVE before a medical procedure or surgery.
  • Severe allergic reactions. Stop taking CONTRAVE and call your healthcare provider or go to the nearest hospital emergency room right away if you have any of the following signs and symptoms of an allergic reaction: rash, itching, hives, fever, swollen lymph glands, painful sores in your mouth or around your eyes, swelling of your lips or tongue, chest pain, or trouble breathing.
  • Increases in blood pressure or heart rate. Some people may get high blood pressure or have a higher heart rate when taking CONTRAVE. Your healthcare provider should check your blood pressure and heart rate before you start taking, and while you take CONTRAVE.
  • Liver damage or hepatitis. Stop taking CONTRAVE and tell your healthcare provider if you have any of the following symptoms of liver problems: stomach area pain lasting more than a few days, dark urine, yellowing of the whites of your eyes, or tiredness. Your healthcare provider may need to stop treating you with CONTRAVE if you get signs or symptoms of a serious liver problem.
  • Manic episodes. Bupropion can cause some people who were manic or depressed in the past to become manic or depressed again.
  • Visual problems (angle-closure glaucoma). Signs and symptoms may include: eye pain, changes in vision, swelling or redness in or around the eye. Talk with your healthcare provider to find out if you are at risk for angle‐closure glaucoma and to get treatment to prevent it if you are at risk.
  • Increased risk of low blood sugar in people with type 2 diabetes mellitus who also take medicines to treat their diabetes (such as insulin or sulfonylureas). You should check your blood sugar before you start taking CONTRAVE and while you take CONTRAVE.

The most common side effects of CONTRAVE include nausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea. These are not all of the possible side effects of CONTRAVE.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

What is CONTRAVE?

CONTRAVE is a prescription weight-loss medicine that may help some adults with a body mass index (BMI) of 30 kg/m2 or greater (obese), or adults with a BMI of 27 kg/m2 or greater (overweight) with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes, lose weight and keep the weight off.

CONTRAVE should be used with a reduced-calorie diet and increased physical activity.

It is not known if CONTRAVE changes your risk of heart problems or stroke or of death due to heart problems or stroke.

It is not known if CONTRAVE is safe and effective when taken with other prescription, over-the-counter, or herbal weight-loss products.

CONTRAVE is not approved to treat depression or other mental illnesses, or to help people quit smoking (smoking cessation).

Please see Full Prescribing Information, including Medication Guide, for CONTRAVE.