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Healthy Ways to Lose Fat—Not Muscle

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When you step on the scale and see the number go down, it’s easy to assume that all weight loss is good weight loss. 
 
But not all pounds are equal. Your body is made up of fat, muscle, bone, and water—so when you lose weight, you want to make sure you’re losing the right kind. Here’s why maintaining muscle is key to long-term health and how you can preserve muscle while working toward your weight loss goals.
 

The Difference Between Fat Loss and Muscle Loss

Fat loss happens when your body burns stored fat for energy, which helps improve overall health, metabolism, and body composition. We’ve talked before about the dangers of visceral (belly) fat. Losing significant amounts of fat, especially in the abdominal area, can have an outsized positive impact on your health.
 
Muscle loss, on the other hand, occurs when the body breaks down muscle tissue. This can occur due to rapid weight loss, inadequate protein intake, or lack of resistance exercise. Losing muscle can slow your metabolism, make it harder to keep weight off, and decrease overall strength and function. While some muscle loss naturally occurs due to aging, losing muscle mass is not generally seen as healthy by the medical community.
 

Why Muscle Mass Matters

Muscle plays a critical role in your body’s metabolism. The more muscle you have, the more calories you burn—even at rest. This is known as your basal metabolic rate (calculate your BMR here). But when you lose both muscle and fat, your metabolism slows down, which can make it easier to regain weight over time.
 
Beyond metabolism, muscle is essential for overall strength, mobility, and daily function. It supports joint health, reduces the risk of injury, and helps maintain balance and coordination, which becomes increasingly important as you age. Strong muscles also contribute to better posture and can help alleviate aches and pains associated with poor movement patterns.
 

Tips on Losing Fat While Preserving Muscle

If you’re on a weight loss journey, it’s important to maintain healthy habits that protect your muscle mass while still allowing you to lose fat. Here are six ways to prioritize building and maintaining muscle mass:

  • Prioritize protein: Eating enough protein helps your body preserve muscle during weight loss. Aim for lean sources like chicken, fish, eggs, tofu, and Greek yogurt. Spreading your protein intake throughout the day can also help maximize muscle retention.
  • Strength train regularly: Resistance exercises, such as weight lifting or bodyweight movements, signal your body to keep muscle even as you lose fat. Aim for at least two to three strength training sessions per week, focusing on major muscle groups. Don’t hesitate to work with a personal trainer if you’re new to weights to ensure you’re prioritizing safety.
  • Don’t cut calories too aggressively: Extreme calorie restriction can lead to muscle loss. A gradual, sustainable calorie deficit—typically 300 to 500 calories per day—is better for long-term success.
  • Stay active: Besides strength training, regular movement—such as walking, stretching, or yoga—helps maintain muscle function and overall health. High-intensity interval training (HIIT) can also be effective for burning fat while preserving muscle.
  • Get enough rest and recovery: Sleep and recovery play a huge role in muscle preservation. Aim for seven to nine hours of sleep per night, and give your muscles time to recover between workouts.
  • Stay hydrated: Proper hydration supports muscle function and overall metabolism. Drinking enough water can also help with digestion and nutrient absorption, ensuring your body gets what it needs to retain muscle.
 Keeping your muscle mass intact while losing weight ensures you’re not just getting smaller, but getting stronger and healthier in the process. By combining the right nutrition and exercise strategies alongside your prescription weight loss medication, you can stay active and strong along your weight loss journey and reach your goals in a healthy and sustainable way!
 
 

CON-2337-001 03/25
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Important Safety Information
What is CONTRAVE?
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CONTRAVE can cause serious side effects including:

Suicidal thoughts or actions: One of the ingredients in CONTRAVE is bupropion. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment.

CONTRAVE is a prescription weight-loss medicine that may help some adults with a body mass index (BMI) of 30 kg/m2 or greater (obese), or adults with a BMI of 27 kg/m2 or greater (overweight) with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes, lose weight and keep the weight off.

Important Safety Information
See More
CONTRAVE can cause serious side effects including:
Suicidal thoughts or actions: One of the ingredients in CONTRAVE is bupropion. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment.
What is CONTRAVE?
See More
CONTRAVE is indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of:
Important Safety Information
What is CONTRAVE?
See Less 

CONTRAVE can cause serious side effects including:

Suicidal thoughts or actions: One of the ingredients in CONTRAVE is bupropion. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment.

While taking CONTRAVE, you or your family members should pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when you start taking CONTRAVE or when your dose changes.

Stop taking CONTRAVE and call a healthcare provider right away if you or your family members notice any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying; attempts to commit suicide; depression; anxiety; feeling agitated or restless; panic attacks; irritability; aggression, anger, or violence; acting on dangerous impulses; an extreme increase in activity and talking; other unusual changes in behavior or mood; trouble sleeping.

CONTRAVE is not approved for use in children under the age of 18.

Do not take CONTRAVE if you have uncontrolled high blood pressure; have or have had seizures; use other medicines that contain bupropion such as WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, APLENZIN and ZYBAN; have or have had an eating disorder called anorexia or bulimia; are dependent on opioid pain medicines or use medicines to help stop taking opioids, or are in opiate withdrawal; drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy), benzodiazepines, or anti‐seizure medicines and stop using them all of a sudden; are taking or have taken medicines called monoamine oxidase inhibitors (MAOIs) in the past 14 days; or are allergic to any of the ingredients in CONTRAVE.

Tell your healthcare provider about all of your medical conditions, including if you have: depression or other mental illnesses; attempted suicide; seizures; head injury; tumor or infection of brain or spine; low blood sugar or low sodium; liver or kidney problems; high blood pressure; heart attack, heart problems, or stroke; eating disorder; drinking a lot of alcohol; prescription medicine or street drug abuse; are 65 or older; diabetes; pregnant or planning to become pregnant; or breastfeeding.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

CONTRAVE may cause serious side effects, including:

  • Seizures. There is a risk of having a seizure when you take CONTRAVE. The risk of seizure is higher in people who take higher doses of CONTRAVE, have certain medical conditions, or take CONTRAVE with certain other medicines. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider has said it is okay to take them. If you have a seizure while taking CONTRAVE, stop taking CONTRAVE and call your healthcare provider right away.

  • Risk of opioid overdose. Do not take large amounts of opioids, including opioid-containing medicines, such as heroin or prescription pain pills, to try to overcome the opioid-blocking effects of naltrexone. This can lead to serious injury, coma, or death.

    Get emergency medical help right away if you take opioids and you:

    • have trouble breathing

    • become very drowsy with slowed breathing

    • have slow, shallow breathing

    • feel faint, very dizzy, confused, or have unusual symptoms

  • Sudden opioid withdrawal. People who take CONTRAVE must not use any type of opioid, including street drugs, prescription pain medicines, cough, cold, or diarrhea medicines that contain opioids, or opioid dependence treatments, for at least 7 to 10 days before starting CONTRAVE. Using opioids in the 7 to 10 days before you start taking CONTRAVE may cause you to suddenly have symptoms of opioid withdrawal when you take it. Sudden opioid withdrawal can be severe, and you may need to go to the hospital. Tell your healthcare provider you are taking CONTRAVE before a medical procedure or surgery.

  • Severe allergic reactions. Stop taking CONTRAVE and call your healthcare provider or go to the nearest hospital emergency room right away if you have any of the following signs and symptoms of an allergic reaction: rash, itching, hives, fever, swollen lymph glands, painful sores in your mouth or around your eyes, swelling of your lips or tongue, chest pain, or trouble breathing.

  • Increases in blood pressure or heart rate. Some people may get high blood pressure or have a higher heart rate when taking CONTRAVE. Your healthcare provider should check your blood pressure and heart rate before you start taking, and while you take CONTRAVE.

  • Liver damage or hepatitis. Stop taking CONTRAVE and tell your healthcare provider if you have any of the following symptoms of liver problems: stomach area pain lasting more than a few days, dark urine, yellowing of the whites of your eyes, or tiredness. Your healthcare provider may need to stop treating you with CONTRAVE if you get signs or symptoms of a serious liver problem.

  • Manic episodes. Bupropion can cause some people who were manic or depressed in the past to become manic or depressed again.

  • Visual problems (angle-closure glaucoma). Signs and symptoms may include: eye pain, changes in vision, swelling or redness in or around the eye. Talk with your healthcare provider to find out if you are at risk for angle‐closure glaucoma and to get treatment to prevent it if you are at risk.

  • Increased risk of low blood sugar in people with type 2 diabetes mellitus who also take medicines to treat their diabetes (such as insulin or sulfonylureas). You should check your blood sugar before you start taking CONTRAVE and while you take CONTRAVE.

The most common side effects of CONTRAVE include nausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea. These are not all of the possible side effects of CONTRAVE.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

What is CONTRAVE?

CONTRAVE is a prescription weight-loss medicine that may help some adults with a body mass index (BMI) of 30 kg/m2 or greater (obese), or adults with a BMI of 27 kg/m2 or greater (overweight) with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes, lose weight and keep the weight off.

CONTRAVE should be used with a reduced-calorie diet and increased physical activity.

It is not known if CONTRAVE changes your risk of heart problems or stroke or of death due to heart problems or stroke.

It is not known if CONTRAVE is safe and effective when taken with other prescription, over-the-counter, or herbal weight-loss products.

CONTRAVE is not approved to treat depression or other mental illnesses, or to help people quit smoking (smoking cessation).

Please see Full Prescribing Information, including Medication Guide, for CONTRAVE.